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Open AccessCommunication
Mar. Drugs 2015, 13(7), 4171-4178; doi:10.3390/md13074171

Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus

1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Chinese Center for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, and College of Pharmacy Sciences, Hebei University, Baoding 071002, China
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes F. Imhoff
Received: 12 May 2015 / Revised: 22 June 2015 / Accepted: 23 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
View Full-Text   |   Download PDF [250 KB, uploaded 7 July 2015]   |  

Abstract

One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (27) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 μM. View Full-Text
Keywords: gorgonian-derived fungus; Cladosporium sp.; bicyclic lactam; 12-membered macrolides; cytotoxic activity gorgonian-derived fungus; Cladosporium sp.; bicyclic lactam; 12-membered macrolides; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cao, F.; Yang, Q.; Shao, C.-L.; Kong, C.-J.; Zheng, J.-J.; Liu, Y.-F.; Wang, C.-Y. Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus. Mar. Drugs 2015, 13, 4171-4178.

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