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Mar. Drugs 2015, 13(5), 2890-2908; doi:10.3390/md13052890

Alginate Hydrogels Coated with Chitosan for Wound Dressing

1
Institute for Polymers, Composites and Biomaterials (IPCB), CNR, via Campi Flegrei 34, Pozzuoli 80078, Italy
2
Institute of Biomolecular Chemistry, CNR, via Campi Flegrei 34, Pozzuoli 80078, Italy
3
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, via L. De Crecchio 7, Naples 80138, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Alejandro M. Mayer
Received: 24 February 2015 / Revised: 2 April 2015 / Accepted: 29 April 2015 / Published: 11 May 2015
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

In this work, a coating of chitosan onto alginate hydrogels was realized using the water-soluble hydrochloride form of chitosan (CH-Cl), with the dual purpose of imparting antibacterial activity and delaying the release of hydrophilic molecules from the alginate matrix. Alginate hydrogels with different calcium contents were prepared by the internal setting method and coated by immersion in a CH-Cl solution. Structural analysis by cryo-scanning electron microscopy was carried out to highlight morphological alterations due to the coating layer. Tests in vitro with human mesenchymal stromal cells (MSC) were assessed to check the absence of toxicity of CH-Cl. Swelling, stability in physiological solution and release characteristics using rhodamine B as the hydrophilic model drug were compared to those of relative uncoated hydrogels. Finally, antibacterial activity against Escherichia coli was tested. Results show that alginate hydrogels coated with chitosan hydrochloride described here can be proposed as a novel medicated dressing by associating intrinsic antimicrobial activity with improved sustained release characteristics. View Full-Text
Keywords: chitosan hydrochloride; alginate; hydrogels; antibacterial activity; sustained release; wound dressing chitosan hydrochloride; alginate; hydrogels; antibacterial activity; sustained release; wound dressing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Straccia, M.C.; d'Ayala, G.G.; Romano, I.; Oliva, A.; Laurienzo, P. Alginate Hydrogels Coated with Chitosan for Wound Dressing. Mar. Drugs 2015, 13, 2890-2908.

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