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Mar. Drugs 2015, 13(4), 2250-2266; doi:10.3390/md13042250

Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease

1
Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, NS B2N 5E3, Canada
2
Aquatic and Crop Resource Development, National Research Council Canada, 1411 Oxford Street, Halifax, NS B3H 3Z1, Canada
3
Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Colin Barrow
Received: 30 January 2015 / Revised: 30 March 2015 / Accepted: 1 April 2015 / Published: 14 April 2015
(This article belongs to the Special Issue Marine Functional Food)
View Full-Text   |   Download PDF [944 KB, uploaded 14 April 2015]   |  

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic Caenorhabditis elegans PD model. We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a corrected slowness of movement. We also showed that the enhancement of oxidative stress tolerance and an up-regulation of the stress response genes, sod-3 and skn-1, may have served as the molecular mechanism for the C. crispus-extract-mediated protection against PD pathology. Altogether, apart from its potential as a functional food, the tested red seaweed, C. crispus, might find promising pharmaceutical applications for the development of potential novel anti-neurodegenerative drugs for humans. View Full-Text
Keywords: Chondrus crispus; neuroprotective effect; oxidative stress; Parkinson’s disease Chondrus crispus; neuroprotective effect; oxidative stress; Parkinson’s disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, J.; Banskota, A.H.; Critchley, A.T.; Hafting, J.; Prithiviraj, B. Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease. Mar. Drugs 2015, 13, 2250-2266.

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