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Mar. Drugs 2015, 13(4), 2158-2182; doi:10.3390/md13042158

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Department of Materials Science and Applied Chemistry, Riga Technical University, Azenes 14/24, Riga, LV-1048, Latvia
Academic Editor: Paola Laurienzo
Received: 19 February 2015 / Revised: 23 March 2015 / Accepted: 26 March 2015 / Published: 13 April 2015
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [579 KB, uploaded 13 April 2015]   |  

Abstract

Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed. View Full-Text
Keywords: chitosan; chitooligosacharides; age-related diseases; protein conformations chitosan; chitooligosacharides; age-related diseases; protein conformations
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kerch, G. The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases. Mar. Drugs 2015, 13, 2158-2182.

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