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Mar. Drugs 2015, 13(4), 1819-1846; doi:10.3390/md13041819

Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, Białystok 15-222, Poland
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 25 February 2015 / Revised: 19 March 2015 / Accepted: 20 March 2015 / Published: 1 April 2015
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [746 KB, uploaded 1 April 2015]   |  


Chitosan—one of the natural multifunctional polymers—due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. However, the problem of poor stability of chitosan-based systems restricts its practical applicability; thus, it has become a great challenge to establish sufficient shelf-life for chitosan formulations. Improved stability can be assessed by controlling the environmental factors, manipulating processing conditions (e.g., temperature), introducing a proper stabilizing compound, developing chitosan blends with another polymer, or modifying the chitosan structure using chemical or ionic agents. This review covers the influence of internal, environmental, and processing factors on the long-term stability of chitosan products. The aim of this paper is also to highlight the latest developments which enable the physicochemical properties of chitosan-based applications to be preserved upon storage. View Full-Text
Keywords: chitosan; drug delivery system; long-term stability; acidic hydrolysis; thermal degradation; storage conditions chitosan; drug delivery system; long-term stability; acidic hydrolysis; thermal degradation; storage conditions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Szymańska, E.; Winnicka, K. Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications. Mar. Drugs 2015, 13, 1819-1846.

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