Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis
AbstractAntifungal bioactivity-guided fractionation of the organic extract of the sponge Polymastia boletiformis, collected from the west coast of Ireland, led to the isolation of two new sulfated steroid-amino acid conjugates (1 and 2). Extensive 1D and 2D NMR analyses in combination with quantum mechanical calculations of the electronic circular dichroism (ECD) spectra, optical rotation, and 13C chemical shifts were used to establish the chemical structures of 1 and 2. Both compounds exhibited moderate antifungal activity against Cladosporium cucumerinum, while compound 2 was also active against Candida albicans. Marine natural products containing steroidal and amino acid constituents are extremely rare in nature. View Full-Text
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Smyrniotopoulos, V.; Rae, M.; Soldatou, S.; Ding, Y.; Wolff, C.W.; McCormack, G.; Coleman, C.M.; Ferreira, D.; Tasdemir, D. Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis. Mar. Drugs 2015, 13, 1632-1646.
Smyrniotopoulos V, Rae M, Soldatou S, Ding Y, Wolff CW, McCormack G, Coleman CM, Ferreira D, Tasdemir D. Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis. Marine Drugs. 2015; 13(4):1632-1646.Chicago/Turabian Style
Smyrniotopoulos, Vangelis; Rae, Margaret; Soldatou, Sylvia; Ding, Yuanqing; Wolff, Carsten W.; McCormack, Grace; Coleman, Christina M.; Ferreira, Daneel; Tasdemir, Deniz. 2015. "Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis." Mar. Drugs 13, no. 4: 1632-1646.