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Mar. Drugs 2015, 13(3), 1389-1409; doi:10.3390/md13031389

New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis

Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
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Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 9 January 2015 / Revised: 17 February 2015 / Accepted: 4 March 2015 / Published: 16 March 2015
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Abstract

Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites. View Full-Text
Keywords: alkaloid; bromotyrosine; Pseudoceratina; sponge; Tylodina; antibiotics; marine natural products alkaloid; bromotyrosine; Pseudoceratina; sponge; Tylodina; antibiotics; marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gotsbacher, M.P.; Karuso, P. New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis. Mar. Drugs 2015, 13, 1389-1409.

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