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Mar. Drugs 2015, 13(3), 1124-1132; doi:10.3390/md13031124

Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus

1
Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China
2
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
3
Shandong Provincial Key Laboratory of Test Technology for Material Chemical Safety, Jinan 250014, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kirk Gustafson
Received: 24 November 2014 / Revised: 8 February 2015 / Accepted: 13 February 2015 / Published: 2 March 2015
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
View Full-Text   |   Download PDF [423 KB, uploaded 2 March 2015]   |  

Abstract

One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC50 values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity. View Full-Text
Keywords: Epicoccum sp.; secondary metabolites; isopimarane diterpene; X-ray diffraction; α-glucosidase inhibitory activity Epicoccum sp.; secondary metabolites; isopimarane diterpene; X-ray diffraction; α-glucosidase inhibitory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xia, X.; Qi, J.; Liu, Y.; Jia, A.; Zhang, Y.; Liu, C.; Gao, C.; She, Z. Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus. Mar. Drugs 2015, 13, 1124-1132.

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