Next Article in Journal
Marine Drugs Best Paper Award 2015
Next Article in Special Issue
Anti-Obesity Activity of the Marine Carotenoid Fucoxanthin
Previous Article in Journal
Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
Previous Article in Special Issue
Enzyme-Assisted Extraction of Bioactive Material from Chondrus crispus and Codium fragile and Its Effect on Herpes simplex Virus (HSV-1)
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(2), 1051-1067; doi:10.3390/md13021051

Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells

1
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea
2
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
3
Department of Life Science, Gachon University, Seongnam 461-701, Korea
4
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea
5
Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea
6
The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea
7
Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea
These authors are equally contributed to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Colin Barrow
Received: 31 December 2014 / Revised: 30 January 2015 / Accepted: 10 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Marine Functional Food)
View Full-Text   |   Download PDF [625 KB, uploaded 24 February 2015]   |  

Abstract

Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions. View Full-Text
Keywords: fucoidan; transforming growth factor beta 1; cyclooxygenase-2; alcohol; liver fucoidan; transforming growth factor beta 1; cyclooxygenase-2; alcohol; liver
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lim, J.D.; Lee, S.R.; Kim, T.; Jang, S.-A.; Kang, S.C.; Koo, H.J.; Sohn, E.; Bak, J.P.; Namkoong, S.; Kim, H.K.; Song, I.S.; Kim, N.; Sohn, E.-H.; Han, J. Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells. Mar. Drugs 2015, 13, 1051-1067.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top