Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Khalid A. El Sayed
Received: 5 January 2015 / Revised: 5 February 2015 / Accepted: 6 February 2015 / Published: 13 February 2015
Two new briarane-type diterpenoids, briarenolides K (1
) and L (2
), were isolated from an octocoral identified as Briareum
sp. The structures of new briaranes 1
were elucidated by spectroscopic methods. In the in vitro
anti-inflammatory effects test, briaranes 1
were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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Su, Y.-D.; Su, T.-R.; Wen, Z.-H.; Hwang, T.-L.; Fang, L.-S.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Mar. Drugs 2015, 13, 1037-1050.
Su Y-D, Su T-R, Wen Z-H, Hwang T-L, Fang L-S, Chen J-J, Wu Y-C, Sheu J-H, Sung P-J. Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Marine Drugs. 2015; 13(2):1037-1050.
Su, Yin-Di; Su, Tzu-Rong; Wen, Zhi-Hong; Hwang, Tsong-Long; Fang, Lee-Shing; Chen, Jih-Jung; Wu, Yang-Chang; Sheu, Jyh-Horng; Sung, Ping-Jyun. 2015. "Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)." Mar. Drugs 13, no. 2: 1037-1050.
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