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Mar. Drugs 2015, 13(2), 1037-1050; doi:10.3390/md13021037

Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

1
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
4
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
5
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
6
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
7
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
9
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
11
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
12
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Khalid A. El Sayed
Received: 5 January 2015 / Revised: 5 February 2015 / Accepted: 6 February 2015 / Published: 13 February 2015
View Full-Text   |   Download PDF [710 KB, uploaded 24 February 2015]   |  

Abstract

Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. View Full-Text
Keywords: Briareum; briarane; octocoral; anti-inflammatory; iNOS Briareum; briarane; octocoral; anti-inflammatory; iNOS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Su, Y.-D.; Su, T.-R.; Wen, Z.-H.; Hwang, T.-L.; Fang, L.-S.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Mar. Drugs 2015, 13, 1037-1050.

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