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Mar. Drugs 2015, 13(2), 1026-1036; doi:10.3390/md13021026

Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice

1
Laboratory for Lipid Medicine and Technology (LLMT), Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
2
Nutrition Department, People's Liberation Army General Hospital, Beijing 100853, China
3
Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong 524023, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Gilles Barnathan
Received: 24 November 2014 / Revised: 30 January 2015 / Accepted: 2 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Marine Lipids)
View Full-Text   |   Download PDF [1053 KB, uploaded 24 February 2015]   |  

Abstract

Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight and the expression of Toll-like receptor 4 (TLR4) pathway components. LPS administration induced a dramatic loss of body weight within two days. Treatment with n-3 PUFA not only stopped loss of body weight but also gradually reversed it back to baseline levels within one week. Accordingly, the animals treated with n-3 PUFA exhibited markedly lower levels of inflammatory cytokines or markers in plasma and tissues, as well as down-regulation of TLR4 pathway components compared to animals without n-3 PUFA treatment or those treated with omega-6 PUFA. Our data demonstrate that n-3 PUFA intervention can suppress LPS-induced inflammation and weight loss via, at least in part, down-regulation of pro-inflammatory targets of the TLR4 signaling pathway, and highlight the therapeutic potential of n-3 PUFA in the management of sepsis. View Full-Text
Keywords: n-3 polyunsaturated fatty acids; lipopolysaccharide; inflammation; muscle atrophy; TLR4; sepsis n-3 polyunsaturated fatty acids; lipopolysaccharide; inflammation; muscle atrophy; TLR4; sepsis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, Y.-H.; Li, X.-Y.; Chen, C.-Y.; Zhang, H.-M.; Kang, J.X. Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice. Mar. Drugs 2015, 13, 1026-1036.

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