Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry
AbstractAzaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and death. Although it is well known that azaspiracid-1 is toxic to most cells and cell lines, little is known about its biological target(s). A rat PC12 cell line, commonly used as a model for the peripheral nervous system, was used to study the neurotoxicological effects of azaspiracid-1. Azaspiracid-1 induced differentiation-related morphological changes followed by a latter cell death. The differentiated phenotype showed peripherin-labelled neurite-like processes simultaneously as a specific isoform of peripherin was down-regulated. The precise mechanism behind this down-regulation remains uncertain. However, this study provides new insights into the neurological effects of azaspiracid-1 and into the biological significance of specific isoforms of peripherin. View Full-Text
- Supplementary File 1:
Supplementary (DOCX, 177 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Hjørnevik, L.V.; Frøyset, A.K.; Grønset, T.A.; Rungruangsak-Torrissen, K.; Fladmark, K.E. Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry. Mar. Drugs 2015, 13, 7390-7402.
Hjørnevik LV, Frøyset AK, Grønset TA, Rungruangsak-Torrissen K, Fladmark KE. Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry. Marine Drugs. 2015; 13(12):7390-7402.Chicago/Turabian Style
Hjørnevik, Linda V.; Frøyset, Ann K.; Grønset, Toril A.; Rungruangsak-Torrissen, Krisna; Fladmark, Kari E. 2015. "Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry." Mar. Drugs 13, no. 12: 7390-7402.