Next Article in Journal
Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
Next Article in Special Issue
Genipin-Crosslinked Chitosan Gels and Scaffolds for Tissue Engineering and Regeneration of Cartilage and Bone
Previous Article in Journal
Purification and Characterization of Cathepsin B from the Muscle of Horse Mackerel Trachurus japonicus
Previous Article in Special Issue
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2015, 13(11), 6566-6587; doi:10.3390/md13116566

Chitosanases from Family 46 of Glycoside Hydrolases: From Proteins to Phenotypes

Biologie, Faculté des Sciences, Université de Sherbrooke, 2500, boul. de l’Université, Sherbrooke, QC J1K 2R1, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 31 August 2015 / Revised: 9 October 2015 / Accepted: 13 October 2015 / Published: 28 October 2015
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
View Full-Text   |   Download PDF [2141 KB, uploaded 28 October 2015]   |  

Abstract

Chitosanases, enzymes that catalyze the endo-hydrolysis of glycolytic links in chitosan, are the subject of numerous studies as biotechnological tools to generate low molecular weight chitosan (LMWC) or chitosan oligosaccharides (CHOS) from native, high molecular weight chitosan. Glycoside hydrolases belonging to family GH46 are among the best-studied chitosanases, with four crystallography-derived structures available and more than forty enzymes studied at the biochemical level. They were also subjected to numerous site-directed mutagenesis studies, unraveling the molecular mechanisms of hydrolysis. This review is focused on the taxonomic distribution of GH46 proteins, their multi-modular character, the structure-function relationships and their biological functions in the host organisms. View Full-Text
Keywords: chitosan; chitosanase; glycoside hydrolase; Streptomyces; Bacillus; Microbacterium; hydrolysis; polysaccharide; chlorovirus chitosan; chitosanase; glycoside hydrolase; Streptomyces; Bacillus; Microbacterium; hydrolysis; polysaccharide; chlorovirus
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Viens, P.; Lacombe-Harvey, M.-È.; Brzezinski, R. Chitosanases from Family 46 of Glycoside Hydrolases: From Proteins to Phenotypes. Mar. Drugs 2015, 13, 6566-6587.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top