Next Article in Journal
Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action
Next Article in Special Issue
Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum
Previous Article in Journal
Matrix Production, Pigment Synthesis, and Sporulation in a Marine Isolated Strain of Bacillus pumilus
Previous Article in Special Issue
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(10), 6489-6504; doi:10.3390/md13106489

Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32

1
Key Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China
2
Institute of Biology, Shandong Academy of Sciences; Research and Development Platform for Drug Screening of Shandong Academy of Sciences, Jinan 250014, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 22 August 2015 / Revised: 2 October 2015 / Accepted: 9 October 2015 / Published: 22 October 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [1182 KB, uploaded 22 October 2015]   |  

Abstract

Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5–7, and 9–12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher’s and Marfey’s methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4–6 and 8–12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds. View Full-Text
Keywords: marine-derived fungus; Penicillium expansum; secondary metabolites; alkaloids; cardiovascular effects marine-derived fungus; Penicillium expansum; secondary metabolites; alkaloids; cardiovascular effects
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fan, Y.-Q.; Li, P.-H.; Chao, Y.-X.; Chen, H.; Du, N.; He, Q.-X.; Liu, K.-C. Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32. Mar. Drugs 2015, 13, 6489-6504.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top