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Mar. Drugs 2015, 13(10), 6366-6383; doi:10.3390/md13106366

Recent Advances in Drug Discovery from South African Marine Invertebrates

1
Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa
2
Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Sylvia Urban
Received: 25 July 2015 / Revised: 28 September 2015 / Accepted: 29 September 2015 / Published: 14 October 2015
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Abstract

Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from C. gilchristi and Lissoclinum sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant Staphylococcus aureus (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, cis-3,4-dihydrohamacanthin B and bromodeoxytopsentin from T. pachastrelloides, are compared. View Full-Text
Keywords: cephalostatin; mandelalide; methicillin resistant Staphylococcus aureus; MRSA PK; bisindole alkaloids cephalostatin; mandelalide; methicillin resistant Staphylococcus aureus; MRSA PK; bisindole alkaloids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Davies-Coleman, M.T.; Veale, C.G.L. Recent Advances in Drug Discovery from South African Marine Invertebrates. Mar. Drugs 2015, 13, 6366-6383.

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