Next Article in Journal
Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses
Next Article in Special Issue
Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells
Previous Article in Journal
Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages
Previous Article in Special Issue
Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2015, 13(10), 6366-6383; doi:10.3390/md13106366

Recent Advances in Drug Discovery from South African Marine Invertebrates

Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa
Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
Author to whom correspondence should be addressed.
Academic Editor: Sylvia Urban
Received: 25 July 2015 / Revised: 28 September 2015 / Accepted: 29 September 2015 / Published: 14 October 2015
View Full-Text   |   Download PDF [2273 KB, uploaded 14 October 2015]   |  


Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from C. gilchristi and Lissoclinum sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant Staphylococcus aureus (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, cis-3,4-dihydrohamacanthin B and bromodeoxytopsentin from T. pachastrelloides, are compared. View Full-Text
Keywords: cephalostatin; mandelalide; methicillin resistant Staphylococcus aureus; MRSA PK; bisindole alkaloids cephalostatin; mandelalide; methicillin resistant Staphylococcus aureus; MRSA PK; bisindole alkaloids

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Davies-Coleman, M.T.; Veale, C.G.L. Recent Advances in Drug Discovery from South African Marine Invertebrates. Mar. Drugs 2015, 13, 6366-6383.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top