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Mar. Drugs 2015, 13(10), 6306-6318; doi:10.3390/md13106306

Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#

1,†
,
2,3,†
,
1
,
2,4,* , 1,* and 3,4,5
1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China
3
Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China
4
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
5
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Olivier Grovel
Received: 13 August 2015 / Accepted: 26 September 2015 / Published: 10 October 2015
View Full-Text   |   Download PDF [652 KB, uploaded 10 October 2015]   |  

Abstract

Six new compounds with polyketide decalin ring, peaurantiogriseols A–F (16), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1- (1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,6-trimethyl-1-naphthalenyl) (8), were isolated from the fermentation products of mangrove endophytic fungus Penicillium aurantiogriseum 328#. Their structures were elucidated based on their structure analysis. The absolute configurations of compounds 1 and 2 were determined by 1H NMR analysis of their Mosher esters; the absolute configurations of 36 were determined by using theoretical calculations of electronic circular dichroism (ECD). Compounds 18 showed low inhibitory activity against human aldose reductase, no activity of inducing neurite outgrowth, nor antimicrobial activity. View Full-Text
Keywords: mangrove endophytic fungi; Penicillium aurantiogriseum; secondary metabolites; polyketide decalin derivative mangrove endophytic fungi; Penicillium aurantiogriseum; secondary metabolites; polyketide decalin derivative
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ma, Y.; Li, J.; Huang, M.; Liu, L.; Wang, J.; Lin, Y. Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#. Mar. Drugs 2015, 13, 6306-6318.

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