Mar. Drugs 2014, 12(8), 4677-4692; doi:10.3390/md12084677
New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea
Chia-Ching Liaw 1,2, Yuan-Bin Cheng 1,3
, Yun-Sheng Lin 1,4, Yao-Haur Kuo 5, Tsong-Long Hwang 6 and Ya-Ching Shen 1,*
, Yun-Sheng Lin 1,4, Yao-Haur Kuo 5, Tsong-Long Hwang 6 and Ya-Ching Shen 1,*
1
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
3
Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Department of Biological Science & Technology, Mei Ho University, Pingtung 912, Taiwan
5
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
6
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 May 2014 / Revised: 24 July 2014 / Accepted: 24 July 2014 / Published: 22 August 2014
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
Abstract
Ten new briarane diterpenoids, briaviolides A–J (1–10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H–1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/ Cytochalasin B (fMLP/CB). View Full-Text
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
Liaw, C.-C.; Cheng, Y.-B.; Lin, Y.-S.; Kuo, Y.-H.; Hwang, T.-L.; Shen, Y.-C. New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea. Mar. Drugs 2014, 12, 4677-4692.
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