Next Article in Journal
Characterization of an Alginate Lyase, FlAlyA, from Flavobacterium sp. Strain UMI-01 and Its Expression in Escherichia coli
Next Article in Special Issue
Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus
Previous Article in Journal
Localization and Characterization of Ferritin in Demospongiae: A Possible Role on Spiculogenesis
Previous Article in Special Issue
Structural Elucidation of Novel Saponins in the Sea Cucumber Holothuria lessoni
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2014, 12(8), 4677-4692; doi:10.3390/md12084677

New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea

1
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
3
Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Department of Biological Science & Technology, Mei Ho University, Pingtung 912, Taiwan
5
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
6
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 May 2014 / Revised: 24 July 2014 / Accepted: 24 July 2014 / Published: 22 August 2014
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [1198 KB, uploaded 24 February 2015]   |  

Abstract

Ten new briarane diterpenoids, briaviolides A–J (110), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H–1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/ Cytochalasin B (fMLP/CB). View Full-Text
Keywords: Briareum violacea; briarane diterpenoids; briaviolides; anti-inflammatory activities Briareum violacea; briarane diterpenoids; briaviolides; anti-inflammatory activities
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liaw, C.-C.; Cheng, Y.-B.; Lin, Y.-S.; Kuo, Y.-H.; Hwang, T.-L.; Shen, Y.-C. New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea. Mar. Drugs 2014, 12, 4677-4692.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top