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Mar. Drugs 2014, 12(8), 4578-4592; doi:10.3390/md12084578

Lipids and Fatty Acids of Nudibranch Mollusks: Potential Sources of Bioactive Compounds

1
Institute of Marine Biology, Far East Branch, Russian Academy of Sciences, Vladivostok 690041, Russia
2
School of Biomedicine, Far Eastern Federal University, Vladivostok 690950, Russia 
Received: 31 March 2014 / Revised: 7 July 2014 / Accepted: 9 July 2014 / Published: 19 August 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

The molecular diversity of chemical compounds found in marine animals offers a good chance for the discovery of novel bioactive compounds of unique structures and diverse biological activities. Nudibranch mollusks, which are not protected by a shell and produce chemicals for various ecological uses, including defense against predators, have attracted great interest for their lipid composition. Lipid analysis of eight nudibranch species revealed dominant phospholipids, sterols and monoalkyldiacylglycerols. Among polar lipids, 1-alkenyl-2-acyl glycerophospholipids (plasmalogens) and ceramide-aminoethyl phosphonates were found in the mollusks. The fatty acid compositions of the nudibranchs differed greatly from those of other marine gastropods and exhibited a wide diversity: very long chain fatty acids known as demospongic acids, a series of non-methylene-interrupted fatty acids, including unusual 21:2∆7,13, and an abundance of various odd and branched fatty acids typical of bacteria. Symbiotic bacteria revealed in some species of nudibranchs participate presumably in the production of some compounds serving as a chemical defense for the mollusks. The unique fatty acid composition of the nudibranchs is determined by food supply, inherent biosynthetic activities and intracellular symbiotic microorganisms. The potential of nudibranchs as a source of biologically active lipids and fatty acids is also discussed. View Full-Text
Keywords: mollusks; symbiotic bacteria; fatty acids; phospholipids mollusks; symbiotic bacteria; fatty acids; phospholipids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhukova, N.V. Lipids and Fatty Acids of Nudibranch Mollusks: Potential Sources of Bioactive Compounds. Mar. Drugs 2014, 12, 4578-4592.

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