Mar. Drugs 2014, 12(6), 3116-3137; doi:10.3390/md12063116
Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp. 16-02-1
1
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2
College of Pharmacy, Guangxi Medical University, Nanning 530021, China
3
Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou 425100, China
4
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 March 2014 / Revised: 12 April 2014 / Accepted: 16 April 2014 / Published: 27 May 2014
Abstract
Nine new C9 polyketides, named aspiketolactonol (1), aspilactonols A–F (2–7), aspyronol (9) and epiaspinonediol (11), were isolated together with five known polyketides, (S)-2-(2′-hydroxyethyl)-4-methyl-γ-butyrolactone (8), dihydroaspyrone (10), aspinotriol A (12), aspinotriol B (13) and chaetoquadrin F (14), from the secondary metabolites of an Aspergillus sp. 16-02-1 that was isolated from a deep-sea sediment sample. Structures of the new compounds, including their absolute configurations, were determined by spectroscopic methods, especially the 2D NMR, circular dichroism (CD), Mo2-induced CD and Mosher’s 1H NMR analyses. Compound 8 was isolated from natural sources for the first time, and the possible biosynthetic pathways for 1–14 were also proposed and discussed. Compounds 1–14 inhibited human cancer cell lines, K562, HL-60, HeLa and BGC-823, to varying extents. View Full-TextKeywords:
Aspergillus sp. 16-02-1; fungal strain from deep sea sediment; aspiketolactonol; aspilactonol; aspyronol; lactone; epiaspinonediol; polyketide; structure; cytotoxicity
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Chen, X.-W.; Li, C.-W.; Cui, C.-B.; Hua, W.; Zhu, T.-J.; Gu, Q.-Q. Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp. 16-02-1. Mar. Drugs 2014, 12, 3116-3137.
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