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Mar. Drugs 2014, 12(6), 3116-3137; doi:10.3390/md12063116

Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp. 16-02-1

1
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2
College of Pharmacy, Guangxi Medical University, Nanning 530021, China
3
Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou 425100, China
4
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 March 2014 / Revised: 12 April 2014 / Accepted: 16 April 2014 / Published: 27 May 2014
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Abstract

Nine new C9 polyketides, named aspiketolactonol (1), aspilactonols A–F (27), aspyronol (9) and epiaspinonediol (11), were isolated together with five known polyketides, (S)-2-(2′-hydroxyethyl)-4-methyl-γ-butyrolactone (8), dihydroaspyrone (10), aspinotriol A (12), aspinotriol B (13) and chaetoquadrin F (14), from the secondary metabolites of an Aspergillus sp. 16-02-1 that was isolated from a deep-sea sediment sample. Structures of the new compounds, including their absolute configurations, were determined by spectroscopic methods, especially the 2D NMR, circular dichroism (CD), Mo2-induced CD and Mosher’s 1H NMR analyses. Compound 8 was isolated from natural sources for the first time, and the possible biosynthetic pathways for 114 were also proposed and discussed. Compounds 114 inhibited human cancer cell lines, K562, HL-60, HeLa and BGC-823, to varying extents. View Full-Text
Keywords: Aspergillus sp. 16-02-1; fungal strain from deep sea sediment; aspiketolactonol; aspilactonol; aspyronol; lactone; epiaspinonediol; polyketide; structure; cytotoxicity Aspergillus sp. 16-02-1; fungal strain from deep sea sediment; aspiketolactonol; aspilactonol; aspyronol; lactone; epiaspinonediol; polyketide; structure; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, X.-W.; Li, C.-W.; Cui, C.-B.; Hua, W.; Zhu, T.-J.; Gu, Q.-Q. Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp. 16-02-1. Mar. Drugs 2014, 12, 3116-3137.

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