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Mar. Drugs 2014, 12(4), 2182-2204; doi:10.3390/md12042182
Article

Pelagia noctiluca (Scyphozoa) Crude Venom Injection Elicits Oxidative Stress and Inflammatory Response in Rats

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Received: 23 January 2014; in revised form: 20 March 2014 / Accepted: 21 March 2014 / Published: 10 April 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Invertebrates)
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Abstract: Cnidarian toxins represent a rich source of biologically active compounds. Since they may act via oxidative stress events, the aim of the present study was to verify whether crude venom, extracted from the jellyfish Pelagia noctiluca, elicits inflammation and oxidative stress processes, known to be mediated by Reactive Oxygen Species (ROS) production, in rats. In a first set of experiments, the animals were injected with crude venom (at three different doses 6, 30 and 60 µg/kg, suspended in saline solution, i.v.) to test the mortality and possible blood pressure changes. In a second set of experiments, to confirm that Pelagia noctiluca crude venom enhances ROS formation and may contribute to the pathophysiology of inflammation, crude venom-injected animals (30 µg/kg) were also treated with tempol, a powerful antioxidant (100 mg/kg i.p., 30 and 60 min after crude venom). Administration of tempol after crude venom challenge, caused a significant reduction of each parameter related to inflammation. The potential effect of Pelagia noctiluca crude venom in the systemic inflammation process has been here demonstrated, adding novel information about its biological activity.
Keywords: crude venom; Pelagia noctiluca; oxidative stress; inflammation; apoptosis; tempol crude venom; Pelagia noctiluca; oxidative stress; inflammation; apoptosis; tempol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bruschetta, G.; Impellizzeri, D.; Morabito, R.; Marino, A.; Ahmad, A.; Spanò, N.; Spada, G.L.; Cuzzocrea, S.; Esposito, E. Pelagia noctiluca (Scyphozoa) Crude Venom Injection Elicits Oxidative Stress and Inflammatory Response in Rats. Mar. Drugs 2014, 12, 2182-2204.

AMA Style

Bruschetta G, Impellizzeri D, Morabito R, Marino A, Ahmad A, Spanò N, Spada GL, Cuzzocrea S, Esposito E. Pelagia noctiluca (Scyphozoa) Crude Venom Injection Elicits Oxidative Stress and Inflammatory Response in Rats. Marine Drugs. 2014; 12(4):2182-2204.

Chicago/Turabian Style

Bruschetta, Giuseppe; Impellizzeri, Daniela; Morabito, Rossana; Marino, Angela; Ahmad, Akbar; Spanò, Nunziacarla; Spada, Giuseppa L.; Cuzzocrea, Salvatore; Esposito, Emanuela. 2014. "Pelagia noctiluca (Scyphozoa) Crude Venom Injection Elicits Oxidative Stress and Inflammatory Response in Rats." Mar. Drugs 12, no. 4: 2182-2204.



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