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Mar. Drugs 2014, 12(4), 1699-1714; doi:10.3390/md12041699
Article

Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain

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Received: 19 December 2013; in revised form: 7 February 2014 / Accepted: 17 February 2014 / Published: 25 March 2014
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Abstract: Eight streptophenazines (A–H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I–K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I–K) also showed moderate activities against PDE 4B.
Keywords: marine natural product; phenazine; Baltic Sea; Streptomyces; Halichondria panicea; HPLC-DAD/MS; fermentation; PDE 4; antibiotic marine natural product; phenazine; Baltic Sea; Streptomyces; Halichondria panicea; HPLC-DAD/MS; fermentation; PDE 4; antibiotic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kunz, A.L.; Labes, A.; Wiese, J.; Bruhn, T.; Bringmann, G.; Imhoff, J.F. Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain. Mar. Drugs 2014, 12, 1699-1714.

AMA Style

Kunz AL, Labes A, Wiese J, Bruhn T, Bringmann G, Imhoff JF. Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain. Marine Drugs. 2014; 12(4):1699-1714.

Chicago/Turabian Style

Kunz, Anna L.; Labes, Antje; Wiese, Jutta; Bruhn, Torsten; Bringmann, Gerhard; Imhoff, Johannes F. 2014. "Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain." Mar. Drugs 12, no. 4: 1699-1714.



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