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Mar. Drugs 2014, 12(2), 746-756; doi:10.3390/md12020746
Article

Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-Derived Fungus Penicillium brefeldianum SD-273

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Received: 21 November 2013; in revised form: 10 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
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Abstract: Three new indolediketopiperazine peroxides, namely, 24-hydroxyverruculogen (1), 26-hydroxyverruculogen (2), and 13-O-prenyl-26-hydroxyverruculogen (3), along with four known homologues (47), were isolated and identified from the culture extract of the marine sediment-derived fungus Penicillium brefeldianum SD-273. Their structures were determined based on the extensive spectroscopic analysis and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of compounds 13 was determined using chiral HPLC analysis of their acidic hydrolysates. Each of the isolated compounds was evaluated for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
Keywords: marine sediment; Penicillium brefeldianum SD-273; indolediketopiperazine; brine shrimp lethality marine sediment; Penicillium brefeldianum SD-273; indolediketopiperazine; brine shrimp lethality
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

An, C.-Y.; Li, X.-M.; Li, C.-S.; Xu, G.-M.; Wang, B.-G. Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-Derived Fungus Penicillium brefeldianum SD-273. Mar. Drugs 2014, 12, 746-756.

AMA Style

An C-Y, Li X-M, Li C-S, Xu G-M, Wang B-G. Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-Derived Fungus Penicillium brefeldianum SD-273. Marine Drugs. 2014; 12(2):746-756.

Chicago/Turabian Style

An, Chun-Yan; Li, Xiao-Ming; Li, Chun-Shun; Xu, Gang-Ming; Wang, Bin-Gui. 2014. "Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-Derived Fungus Penicillium brefeldianum SD-273." Mar. Drugs 12, no. 2: 746-756.


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