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Mar. Drugs 2014, 12(2), 1148-1156; doi:10.3390/md12021148
Article

Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi

1
, 1
, 2
 and 1,3,4,5,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan 3 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 4 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 22 January 2014 / Accepted: 7 February 2014 / Published: 21 February 2014
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Abstract

Three new eunicellin-type diterpenoids, krempfielins N–P (13), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
Keywords: Cladiella krempfi; eunicellin-type diterpenoid; anti-inflammatory agent; elastase Cladiella krempfi; eunicellin-type diterpenoid; anti-inflammatory agent; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lee, Y.-N.; Tai, C.-J.; Hwang, T.-L.; Sheu, J.-H. Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi. Mar. Drugs 2014, 12, 1148-1156.

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