Next Article in Journal
Marine Drugs Best Paper Award 2014
Previous Article in Journal
The Marine Sponge-Derived Inorganic Polymers, Biosilica and Polyphosphate, as Morphogenetically Active Matrices/Scaffolds for the Differentiation of Human Multipotent Stromal Cells: Potential Application in 3D Printing and Distraction Osteogenesis
Mar. Drugs 2014, 12(2), 1148-1156; doi:10.3390/md12021148
Article

Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi

1
,
1
,
2
 and
1,3,4,5,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan 3 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 4 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 22 January 2014 / Accepted: 7 February 2014 / Published: 21 February 2014
View Full-Text   |   Download PDF [869 KB, uploaded 24 February 2015]   |  

Abstract

Three new eunicellin-type diterpenoids, krempfielins N–P (13), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
Keywords: Cladiella krempfi; eunicellin-type diterpenoid; anti-inflammatory agent; elastase Cladiella krempfi; eunicellin-type diterpenoid; anti-inflammatory agent; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Lee, Y.-N.; Tai, C.-J.; Hwang, T.-L.; Sheu, J.-H. Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi. Mar. Drugs 2014, 12, 1148-1156.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert