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Mar. Drugs 2014, 12(12), 6178-6189; doi:10.3390/md12126178

Briarane Diterpenoids from the Gorgonian Dichotella gemmacea

Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China
These authors contribute equally to the paper.
Authors to whom correspondence should be addressed.
Received: 21 October 2014 / Revised: 27 November 2014 / Accepted: 8 December 2014 / Published: 18 December 2014
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Seven new briarane diterpenoids, gemmacolides AS-AY (17), were isolated together with ten known analogues (817) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells. View Full-Text
Keywords: structure elucidation; briarane diterpenoids; tumor cell growth inhibitory activity; gorgonian; Dichotella gemmacea structure elucidation; briarane diterpenoids; tumor cell growth inhibitory activity; gorgonian; Dichotella gemmacea

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

La, M.-P.; Li, J.; Li, C.; Tang, H.; Liu, B.-S.; Sun, P.; Zhuang, C.-L.; Li, T.-J.; Zhang, W. Briarane Diterpenoids from the Gorgonian Dichotella gemmacea. Mar. Drugs 2014, 12, 6178-6189.

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