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Mar. Drugs 2014, 12(10), 5316-5327; doi:10.3390/md12105316

Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

1
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
3
Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China
4
Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Received: 6 August 2014 / Revised: 7 October 2014 / Accepted: 8 October 2014 / Published: 23 October 2014
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Abstract

Eight new compounds, sinulolides A–H (18), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation. View Full-Text
Keywords: soft coral; Sinularia sp.; sinulolide; NF-κB soft coral; Sinularia sp.; sinulolide; NF-κB
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yang, B.; Wei, X.; Huang, J.; Lin, X.; Liu, J.; Liao, S.; Wang, J.; Zhou, X.; Wang, L.; Liu, Y. Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.. Mar. Drugs 2014, 12, 5316-5327.

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