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Mar. Drugs 2014, 12(10), 5132-5147; doi:10.3390/md12105132

Effect of Salicornia herbacea on Osteoblastogenesis and Adipogenesis in Vitro

1
Marine Biotechnology Center for Pharmaceuticals and Foods, Silla University, Busan 617-736, Korea
2
Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Korea
3
Department of Organic Material Science and Engineering, Pusan National University, Busan 609-735, Korea
*
Author to whom correspondence should be addressed.
Received: 17 January 2014 / Revised: 9 September 2014 / Accepted: 25 September 2014 / Published: 10 October 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Bone-related complications are among the highest concerning metabolic diseases in the modern world. Bone fragility and susceptibility to fracture increase with age and diseases like osteoporosis. Elevated adipogenesis in bone results in osteoporosis and loss of bone mass when coupled with lack of osteoblastogenesis. In this study the potential effect of Salicornia herbacea extract against osteoporotic conditions was evaluated. Adipogenesis inhibitory effect of S. herbacea has been evidenced by decreased lipid accumulation of differentiating cells and expression levels of crucial adipogenesis markers in 3T3-L1 pre-adipocytes. S. herbacea treatment reduced the lipid accumulation by 25% of the control. In addition, mRNA expression of peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer-binding protein (C/EBP)α and sterol regulatory element binding protein (SREBP)1c were inhibited by the presence of S. herbacea. Bone formation enhancement effect of S. herbacea was also confirmed in MC3T3-E1 pre-osteoblasts. The presence of S. herbacea significantly elevated the alkaline phosphatase (ALP) activity by 120% at a concentration of 100 μg/mL in differentiating osteoblasts. S. herbacea also significantly increased the expression of osteoblastogenesis indicators, ALP, bone morphogenetic protein (BMP)-2, osteocalcin and collagen type I (collagen-I). In conclusion, S. herbacea possess potential to be utilized as a source of anti-osteoporotic agent that can inhibit adipogenesis while promoting osteoblastogenesis. View Full-Text
Keywords: Salicornia herbacea; osteoporosis; adipogenesis; osteoblastogenesis Salicornia herbacea; osteoporosis; adipogenesis; osteoblastogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Karadeniz, F.; Kim, J.-A.; Ahn, B.-N.; Kwon, M.S.; Kong, C.-S. Effect of Salicornia herbacea on Osteoblastogenesis and Adipogenesis in Vitro. Mar. Drugs 2014, 12, 5132-5147.

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