Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.
AbstractTwo novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively. View Full-Text
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Liu, Y.; Zhao, S.; Ding, W.; Wang, P.; Yang, X.; Xu, J. Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.. Mar. Drugs 2014, 12, 5124-5131.
Liu Y, Zhao S, Ding W, Wang P, Yang X, Xu J. Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.. Marine Drugs. 2014; 12(10):5124-5131.Chicago/Turabian Style
Liu, Ying; Zhao, Shizhe; Ding, Wanjing; Wang, Pinmei; Yang, Xianwen; Xu, Jinzhong. 2014. "Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.." Mar. Drugs 12, no. 10: 5124-5131.