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Mar. Drugs 2013, 11(9), 3186-3196; doi:10.3390/md11093186

Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans

1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China 2 Chemical Analysis Department, Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China 3 Naturalis Biodiversity Center, National Museum of Natural History, Leiden 2300, The Netherlands 4 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 28 May 2013 / Revised: 28 June 2013 / Accepted: 12 July 2013 / Published: 26 August 2013
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Four new cembrane-type diterpenoids, sarcophyolides B–E (14), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 14 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.
Keywords: soft coral; Sarcophyton elegans; sarcophyolide; cembranoid; cytotoxicity soft coral; Sarcophyton elegans; sarcophyolide; cembranoid; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xi, Z.; Bie, W.; Chen, W.; Liu, D.; Ofwegen, L.V.; Proksch, P.; Lin, W. Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans. Mar. Drugs 2013, 11, 3186-3196.

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