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Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
Chemical Analysis Department, Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China
Naturalis Biodiversity Center, National Museum of Natural History, Leiden 2300, The Netherlands
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 28 May 2013; in revised form: 28 June 2013 / Accepted: 12 July 2013 / Published: 26 August 2013
Abstract: Four new cembrane-type diterpenoids, sarcophyolides B–E (1–4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1–4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.
Keywords: soft coral; Sarcophyton elegans; sarcophyolide; cembranoid; cytotoxicity
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MDPI and ACS Style
Xi, Z.; Bie, W.; Chen, W.; Liu, D.; Ofwegen, L.V.; Proksch, P.; Lin, W. Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans. Mar. Drugs 2013, 11, 3186-3196.
Xi Z, Bie W, Chen W, Liu D, Ofwegen LV, Proksch P, Lin W. Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans. Marine Drugs. 2013; 11(9):3186-3196.
Xi, Zhifang; Bie, Wei; Chen, Wei; Liu, Dong; Ofwegen, Leen V.; Proksch, Peter; Lin, Wenhan. 2013. "Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans." Mar. Drugs 11, no. 9: 3186-3196.