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Mar. Drugs 2013, 11(9), 3155-3167; doi:10.3390/md11093155

Silaffins of Diatoms: From Applied Biotechnology to Biomedicine

1 Analytical Center of Mineralogical and Geochemical Studies, Institute of Geology and Nature Management Far Eastern Branch, Russian Academy of Sciences, 1 Relochny Lane, Blagoveshchensk 675000, Russian Federation 2 Laboratory of Nanotoxicology, Engineering School, Far Eastern Federal University, 37 Pushkinskaya street, Vladivostok 690950, Russian Federation
* Author to whom correspondence should be addressed.
Received: 13 May 2013 / Revised: 29 July 2013 / Accepted: 12 August 2013 / Published: 26 August 2013
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Silaffins are involved in the formation of the cell walls of diatoms. It is known that silaffins can precipitate silica in vitro, forming nano- and micro-particles in the shape of spheres and plates containing many pores. It is important to note that the deposition of silica and the particle morphology in the presence of silaffins affects chemical and physical agents (e.g., peptides, polyamines, phosphate, nitrogen, and the mechanical changes of the reaction mixture). It is believed that silaffins act as an organic matrix for silica-genesis and that silica pore size should reflect the pattern of a matrix. Here, biotechnology related to silaffins is discussed in the context of “a hypothesis of silaffin matrix” and “the LCPA-phosphate model”. We discuss the most promising area of silaffin biotechnology—the development of production methods for silicon structures with desired shapes and nanostructural properties that can be used to create biocompatible materials.
Keywords: silaffins; diatoms; silicon; nanomaterials; medicine silaffins; diatoms; silicon; nanomaterials; medicine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pamirsky, I.E.; Golokhvast, K.S. Silaffins of Diatoms: From Applied Biotechnology to Biomedicine. Mar. Drugs 2013, 11, 3155-3167.

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