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Fucoidans as Potential Inhibitors of HIV-1
Laboratory of Cell Biology, Engelhardt-Institute of Molecular Biology, Moscow 119991, Russia
Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159 100-Let Vladivostoku Ave., Vladivostok 690022, Russia
Research Department of Cell and Gene Therapy, Clinic for Stem Cell Transplantation, UCCH, University Medical Center Hamburg-Eppendorf (UKE), Hamburg D-20246, Germany
* Author to whom correspondence should be addressed.
Received: 10 May 2013; in revised form: 26 June 2013 / Accepted: 31 July 2013 / Published: 19 August 2013
Abstract: The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001–100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001–0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.
Keywords: fucoidan; brown algae; antiviral activity; human immunodeficiency virus type 1
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Prokofjeva, M.M.; Imbs, T.I.; Shevchenko, N.M.; Spirin, P.V.; Horn, S.; Fehse, B.; Zvyagintseva, T.N.; Prassolov, V.S. Fucoidans as Potential Inhibitors of HIV-1. Mar. Drugs 2013, 11, 3000-3014.
Prokofjeva MM, Imbs TI, Shevchenko NM, Spirin PV, Horn S, Fehse B, Zvyagintseva TN, Prassolov VS. Fucoidans as Potential Inhibitors of HIV-1. Marine Drugs. 2013; 11(8):3000-3014.
Prokofjeva, Maria M.; Imbs, Tatyana I.; Shevchenko, Natalya M.; Spirin, Pavel V.; Horn, Stefan; Fehse, Boris; Zvyagintseva, Tatyana N.; Prassolov, Vladimir S. 2013. "Fucoidans as Potential Inhibitors of HIV-1." Mar. Drugs 11, no. 8: 3000-3014.