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Mar. Drugs 2013, 11(7), 2282-2292; doi:10.3390/md11072282
Article

Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

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Received: 3 May 2013 / Revised: 4 June 2013 / Accepted: 9 June 2013 / Published: 27 June 2013
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Abstract

A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.
Keywords: marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Legrave, N.; Hamrouni-Buonomo, S.; Dufies, M.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Mar. Drugs 2013, 11, 2282-2292.

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