Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

doi:10.3390/md11072282

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Mar. Drugs 2013, 11(7), 2282-2292; doi:10.3390/md11072282

Article

Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

Nathalie Legrave¹, Souhir Hamrouni-Buonomo^1,2, Maeva Dufies³, Vincent Guérineau⁴, Jean Vacelet⁵, Patrick Auberger³, Philippe Amade¹ and Mohamed Mehiri^1,*

¹ Chemistry Institute of Nice (ICN), UMR 7272 CNRS, Bioactive Molecules, University of Nice-Sophia Antipolis, ParcValrose, F-06108 Nice Cedex 02, France ² UR Ecosystems and Aquatic Ressources (UR03AGRO1), Agronomic National Institute of Tunisia (INAT), Carthage University, 43 Avenue Charles Nicolle, Tunis 1082, Tunisia ³ Mediterranean Centre of Molecular Medicine (C3M), INSERM UMR 1065, Team 2: Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Route de Saint-Antoine de Ginestière, BP2 3194, 06204 Nice Cedex 3, France ⁴ Gif Research Centre, Chemistry Institute of Natural Substances, CNRS Avenue de la Terrasse, 91198 Gif-Sur-Yvette Cedex, France ⁵ Aix-Marseille University, CNRS UMR 7263, Mediterranean Institute of Biodiversity and Marine and Continental Ecology (IMBE), Station Marine d'Endoume, Rue de la Batterie des Lions, Marseille 13007, France

* Author to whom correspondence should be addressed.

Received: 3 May 2013; in revised form: 4 June 2013 / Accepted: 9 June 2013 / Published: 27 June 2013

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Abstract: A new C₄₇ polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

Keywords: marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida

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MDPI and ACS Style

Legrave, N.; Hamrouni-Buonomo, S.; Dufies, M.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Mar. Drugs 2013, 11, 2282-2292.

AMA Style

Legrave N, Hamrouni-Buonomo S, Dufies M, Guérineau V, Vacelet J, Auberger P, Amade P, Mehiri M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Marine Drugs. 2013; 11(7):2282-2292.

Chicago/Turabian Style

Legrave, Nathalie; Hamrouni-Buonomo, Souhir; Dufies, Maeva; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed. 2013. "Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.." Mar. Drugs 11, no. 7: 2282-2292.

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