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Mar. Drugs 2013, 11(7), 2282-2292; doi:10.3390/md11072282
Article

Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

1
, 1,2
, 3
, 4
, 5
, 3
, 1
 and 1,*
1 Chemistry Institute of Nice (ICN), UMR 7272 CNRS, Bioactive Molecules, University of Nice-Sophia Antipolis, ParcValrose, F-06108 Nice Cedex 02, France 2 UR Ecosystems and Aquatic Ressources (UR03AGRO1), Agronomic National Institute of Tunisia (INAT), Carthage University, 43 Avenue Charles Nicolle, Tunis 1082, Tunisia 3 Mediterranean Centre of Molecular Medicine (C3M), INSERM UMR 1065, Team 2: Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Route de Saint-Antoine de Ginestière, BP2 3194, 06204 Nice Cedex 3, France 4 Gif Research Centre, Chemistry Institute of Natural Substances, CNRS Avenue de la Terrasse, 91198 Gif-Sur-Yvette Cedex, France 5 Aix-Marseille University, CNRS UMR 7263, Mediterranean Institute of Biodiversity and Marine and Continental Ecology (IMBE), Station Marine d'Endoume, Rue de la Batterie des Lions, Marseille 13007, France
* Author to whom correspondence should be addressed.
Received: 3 May 2013 / Revised: 4 June 2013 / Accepted: 9 June 2013 / Published: 27 June 2013
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Abstract

A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.
Keywords: marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Legrave, N.; Hamrouni-Buonomo, S.; Dufies, M.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Mar. Drugs 2013, 11, 2282-2292.

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