Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

doi:10.3390/md11072282

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Mar. Drugs 2013, 11(7), 2282-2292; doi:10.3390/md11072282

Article

Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

Nathalie Legrave¹

, Souhir Hamrouni-Buonomo^1,2

, Maeva Dufies³

, Vincent Guérineau⁴

, Jean Vacelet⁵

, Patrick Auberger³

, Philippe Amade¹

and Mohamed Mehiri^1,*

+ Authors' affiliations

Received: 3 May 2013 / Revised: 4 June 2013 / Accepted: 9 June 2013 / Published: 27 June 2013

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Abstract: A new C₄₇ polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

Keywords: marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary File 1:
Supplemental Information (PDF, 1093 KB)
Supplementary File 2:
3D structure (MOL, 5 KB) Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks.
Supplementary File 3:
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MDPI and ACS Style

Legrave, N.; Hamrouni-Buonomo, S.; Dufies, M.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Mar. Drugs 2013, 11, 2282-2292.

AMA Style

Legrave N, Hamrouni-Buonomo S, Dufies M, Guérineau V, Vacelet J, Auberger P, Amade P, Mehiri M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Marine Drugs. 2013; 11(7):2282-2292.

Chicago/Turabian Style

Legrave, Nathalie; Hamrouni-Buonomo, Souhir; Dufies, Maeva; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed. 2013. "Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.." Mar. Drugs 11, no. 7: 2282-2292.

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