Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

doi:10.3390/md11072282

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Legrave, N
Hamrouni-Buonomo, S
Dufies, M
Guérineau, V
Vacelet, J
Auberger, P
Amade, P
Mehiri, M

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Hamrouni-Buonomo, S
Dufies, M
Guérineau, V
Vacelet, J
Auberger, P
Amade, P
Mehiri, M

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Legrave, N
Hamrouni-Buonomo, S
Dufies, M
Guérineau, V
Vacelet, J
Auberger, P
Amade, P
Mehiri, M

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marine natural products

highly oxygenated polyacetylenes

marine sponges

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Haplosclerida

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Nathalie Legrave

Souhir Hamrouni-Buonomo

Maeva Dufies

Vincent Guérineau

Jean Vacelet

Patrick Auberger

Philippe Amade

Mohamed Mehiri

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Mar. Drugs 2013, 11(7), 2282-2292; doi:10.3390/md11072282

Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

Nathalie Legrave¹

, Souhir Hamrouni-Buonomo^1,2

, Maeva Dufies³

, Vincent Guérineau⁴

, Jean Vacelet⁵

, Patrick Auberger³

, Philippe Amade¹

and Mohamed Mehiri^1,*

Chemistry Institute of Nice (ICN), UMR 7272 CNRS, Bioactive Molecules, University of Nice-Sophia Antipolis, ParcValrose, F-06108 Nice Cedex 02, France

UR Ecosystems and Aquatic Ressources (UR03AGRO1), Agronomic National Institute of Tunisia (INAT), Carthage University, 43 Avenue Charles Nicolle, Tunis 1082, Tunisia

Mediterranean Centre of Molecular Medicine (C3M), INSERM UMR 1065, Team 2: Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Route de Saint-Antoine de Ginestière, BP2 3194, 06204 Nice Cedex 3, France

⁴

Gif Research Centre, Chemistry Institute of Natural Substances, CNRS Avenue de la Terrasse, 91198 Gif-Sur-Yvette Cedex, France

⁵

Aix-Marseille University, CNRS UMR 7263, Mediterranean Institute of Biodiversity and Marine and Continental Ecology (IMBE), Station Marine d'Endoume, Rue de la Batterie des Lions, Marseille 13007, France

Author to whom correspondence should be addressed.

Received: 3 May 2013 / Revised: 4 June 2013 / Accepted: 9 June 2013 / Published: 27 June 2013

View Full-Text | Download PDF [569 KB, uploaded 24 February 2015] |

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Abstract

A new C₄₇ polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines. View Full-Text

Keywords: marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Legrave, N.; Hamrouni-Buonomo, S.; Dufies, M.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Mar. Drugs 2013, 11, 2282-2292.

AMA Style

Legrave N, Hamrouni-Buonomo S, Dufies M, Guérineau V, Vacelet J, Auberger P, Amade P, Mehiri M. Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.. Marine Drugs. 2013; 11(7):2282-2292.

Chicago/Turabian Style

Legrave, Nathalie; Hamrouni-Buonomo, Souhir; Dufies, Maeva; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed. 2013. "Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.." Mar. Drugs 11, no. 7: 2282-2292.

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Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

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