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Mar. Drugs 2013, 11(6), 2230-2238; doi:10.3390/md11062230

Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus

1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
3
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Chunhui Road 17, Yantai 264003, China
*
Authors to whom correspondence should be addressed.
Received: 14 March 2013 / Revised: 24 May 2013 / Accepted: 27 May 2013 / Published: 21 June 2013
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Abstract

Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (510) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM. View Full-Text
Keywords: sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality
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Wang, M.-H.; Li, X.-M.; Li, C.-S.; Ji, N.-Y.; Wang, B.-G. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus. Mar. Drugs 2013, 11, 2230-2238.

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