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Mar. Drugs 2013, 11(6), 1999-2012; doi:10.3390/md11061999
Article

Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis

1,2,†
,
1,2,3,†
,
4
,
1,2
,
5
,
2
,
6
,
2
,
2,3
,
7
,
8,*  and 1,2,3,9,*
Received: 5 March 2013 / Revised: 28 April 2013 / Accepted: 14 May 2013 / Published: 10 June 2013
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Abstract

Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
Keywords: cembrane; diterpenoid; Sinularia flexibilis; elastase cembrane; diterpenoid; Sinularia flexibilis; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, L.-C.; Su, J.-H.; Chiang, M.Y.-N.; Lu, M.-C.; Hwang, T.-L.; Chen, Y.-H.; Hu, W.-P.; Lin, N.-C.; Wang, W.-H.; Fang, L.-S.; Kuo, Y.-H.; Sung, P.-J. Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis. Mar. Drugs 2013, 11, 1999-2012.

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