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Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 March 2013; in revised form: 28 April 2013 / Accepted: 14 May 2013 / Published: 10 June 2013
Abstract: Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
Keywords: cembrane; diterpenoid; Sinularia flexibilis; elastase
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Hu, L.-C.; Su, J.-H.; Chiang, M.Y.-N.; Lu, M.-C.; Hwang, T.-L.; Chen, Y.-H.; Hu, W.-P.; Lin, N.-C.; Wang, W.-H.; Fang, L.-S.; Kuo, Y.-H.; Sung, P.-J. Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis. Mar. Drugs 2013, 11, 1999-2012.
Hu L-C, Su J-H, Chiang MY-N, Lu M-C, Hwang T-L, Chen Y-H, Hu W-P, Lin N-C, Wang W-H, Fang L-S, Kuo Y-H, Sung P-J. Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis. Marine Drugs. 2013; 11(6):1999-2012.
Hu, Li-Chung; Su, Jui-Hsin; Chiang, Michael Y.-N.; Lu, Mei-Chin; Hwang, Tsong-Long; Chen, Yung-Husan; Hu, Wan-Ping; Lin, Nai-Cheng; Wang, Wei-Hsien; Fang, Lee-Shing; Kuo, Yueh-Hsiung; Sung, Ping-Jyun. 2013. "Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis." Mar. Drugs 11, no. 6: 1999-2012.