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Mar. Drugs 2013, 11(6), 1999-2012; doi:10.3390/md11061999
Article

Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis

1,2,†
, 1,2,3,†
, 4
, 1,2
, 5
, 2
, 6
, 2
, 2,3
, 7
, 8,*  and 1,2,3,9,*
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 6 Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 7 Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 8 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan 9 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 5 March 2013 / Revised: 28 April 2013 / Accepted: 14 May 2013 / Published: 10 June 2013
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Abstract

Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
Keywords: cembrane; diterpenoid; Sinularia flexibilis; elastase cembrane; diterpenoid; Sinularia flexibilis; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hu, L.-C.; Su, J.-H.; Chiang, M.Y.-N.; Lu, M.-C.; Hwang, T.-L.; Chen, Y.-H.; Hu, W.-P.; Lin, N.-C.; Wang, W.-H.; Fang, L.-S.; Kuo, Y.-H.; Sung, P.-J. Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis. Mar. Drugs 2013, 11, 1999-2012.

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