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Mar. Drugs 2013, 11(2), 571-580; doi:10.3390/md11020571
Article

New Steroids from the Soft Coral Nephthea chabrolii

1,2
, 3
 and 1,3,*
1 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2013 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 22 February 2013
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Abstract

A new cytotoxic 19-oxygenated steroid, nebrosteroid Q (1) and two new cytotoxic 19-norergosterols, nebrosteroids R and S (2 and 3) were isolated from the soft coral Nephthea chabrolii collected at San-Hsian-Tai. The structures of nebrosteroids Q–S (13) were elucidated by spectral analysis, and their cytotoxicity against selected cancer cells as well as antiviral activity against human cytomegalovirus (HCMV) were measured in vitro.
Keywords: Nephthea chabrolii; 19-oxygenated steroid; norergosterol; cytotoxicity Nephthea chabrolii; 19-oxygenated steroid; norergosterol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, S.-K.; Puu, S.-Y.; Duh, C.-Y. New Steroids from the Soft Coral Nephthea chabrolii. Mar. Drugs 2013, 11, 571-580.

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