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New Steroids from the Soft Coral Nephthea chabrolii
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2013; in revised form: 18 February 2013 / Accepted: 18 February 2013 / Published: 22 February 2013
Abstract: A new cytotoxic 19-oxygenated steroid, nebrosteroid Q (1) and two new cytotoxic 19-norergosterols, nebrosteroids R and S (2 and 3) were isolated from the soft coral Nephthea chabrolii collected at San-Hsian-Tai. The structures of nebrosteroids Q–S (1–3) were elucidated by spectral analysis, and their cytotoxicity against selected cancer cells as well as antiviral activity against human cytomegalovirus (HCMV) were measured in vitro.
Keywords: Nephthea chabrolii; 19-oxygenated steroid; norergosterol; cytotoxicity
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Wang, S.-K.; Puu, S.-Y.; Duh, C.-Y. New Steroids from the Soft Coral Nephthea chabrolii. Mar. Drugs 2013, 11, 571-580.
Wang S-K, Puu S-Y, Duh C-Y. New Steroids from the Soft Coral Nephthea chabrolii. Marine Drugs. 2013; 11(2):571-580.
Wang, Shang-Kwei; Puu, Shyh-Yueh; Duh, Chang-Yih. 2013. "New Steroids from the Soft Coral Nephthea chabrolii." Mar. Drugs 11, no. 2: 571-580.