Mar. Drugs 2013, 11(12), 5148-5158; doi:10.3390/md11125148
Article

Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres

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Received: 1 October 2013; in revised form: 18 November 2013 / Accepted: 4 December 2013 / Published: 16 December 2013
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Abstract: Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair.
Keywords: biomimetic; zinc-tricalcium phosphate; foraminifera; bone defect; bone regeneration
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MDPI and ACS Style

Chou, J.; Hao, J.; Kuroda, S.; Bishop, D.; Ben-Nissan, B.; Milthorpe, B.; Otsuka, M. Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres. Mar. Drugs 2013, 11, 5148-5158.

AMA Style

Chou J, Hao J, Kuroda S, Bishop D, Ben-Nissan B, Milthorpe B, Otsuka M. Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres. Marine Drugs. 2013; 11(12):5148-5158.

Chicago/Turabian Style

Chou, Joshua; Hao, Jia; Kuroda, Shinji; Bishop, David; Ben-Nissan, Besim; Milthorpe, Bruce; Otsuka, Makoto. 2013. "Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres." Mar. Drugs 11, no. 12: 5148-5158.


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