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Mar. Drugs 2013, 11(11), 4585-4593; doi:10.3390/md11114585
Article

Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.

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 and 1,2,8,10,*
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 4 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 7 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 8 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan 9 Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan 10 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Author to whom correspondence should be addressed.
Received: 26 August 2013 / Revised: 17 October 2013 / Accepted: 31 October 2013 / Published: 14 November 2013
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Abstract

A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.
Keywords: eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, T.-H.; Lu, M.-C.; Chang, Y.-C.; Su, Y.-D.; Chen, Y.-H.; Lin, N.-C.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.. Mar. Drugs 2013, 11, 4585-4593.

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