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Mar. Drugs 2013, 11(11), 4585-4593; doi:10.3390/md11114585
Article

Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.

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1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 4 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 7 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 8 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan 9 Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan 10 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Author to whom correspondence should be addressed.
Received: 26 August 2013 / Revised: 17 October 2013 / Accepted: 31 October 2013 / Published: 14 November 2013
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Abstract

A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.
Keywords: eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, T.-H.; Lu, M.-C.; Chang, Y.-C.; Su, Y.-D.; Chen, Y.-H.; Lin, N.-C.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.. Mar. Drugs 2013, 11, 4585-4593.

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