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New Diterpenoids from Soft Coral Sarcophyton ehrenbergi
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 23 September 2013; in revised form: 18 October 2013 / Accepted: 22 October 2013 / Published: 30 October 2013
Abstract: Continuing chemical investigation on the acetone extracts of the soft coral Sarcophyton ehrenbergi collected off the coast of San-hsian-tai, Taitong County, Taiwan led to the isolation of two new diterpenoids, ehrenbergol C and acetyl ehrenberoxide B (1 and 2). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, in vitro tests show that compounds 1 and 2 displayed antiviral activity towards human cytomegalovirus, with EC50 of 20 and 8.0 µg/mL, respectively.
Keywords: Sarcophyton ehrenbergi; diterpenoids; cytotoxicity; anti-HCMV
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MDPI and ACS Style
Wang, S.-K.; Hsieh, M.-K.; Duh, C.-Y. New Diterpenoids from Soft Coral Sarcophyton ehrenbergi. Mar. Drugs 2013, 11, 4318-4327.
Wang S-K, Hsieh M-K, Duh C-Y. New Diterpenoids from Soft Coral Sarcophyton ehrenbergi. Marine Drugs. 2013; 11(11):4318-4327.
Wang, Shang-Kwei; Hsieh, Mu-Keng; Duh, Chang-Yih. 2013. "New Diterpenoids from Soft Coral Sarcophyton ehrenbergi." Mar. Drugs 11, no. 11: 4318-4327.