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Mar. Drugs 2012, 10(6), 1383-1390; doi:10.3390/md10061383
Article

Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator

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Received: 20 April 2012; in revised form: 17 May 2012 / Accepted: 1 June 2012 / Published: 14 June 2012
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Abstract: Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed.
Keywords: sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Teta, R.; Della Sala, G.; Renga, B.; Mangoni, A.; Fiorucci, S.; Costantino, V. Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator. Mar. Drugs 2012, 10, 1383-1390.

AMA Style

Teta R, Della Sala G, Renga B, Mangoni A, Fiorucci S, Costantino V. Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator. Marine Drugs. 2012; 10(6):1383-1390.

Chicago/Turabian Style

Teta, Roberta; Della Sala, Gerardo; Renga, Barbara; Mangoni, Alfonso; Fiorucci, Stefano; Costantino, Valeria. 2012. "Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator." Mar. Drugs 10, no. 6: 1383-1390.


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