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Mar. Drugs 2012, 10(6), 1383-1390; doi:10.3390/md10061383

Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator

1
The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy
2
Department of Clinical and Experimental Medicine, University of Perugia, Via Gerardo Dottori 1, S. Andrea delle Fratte, 06132 Perugia, Italy
*
Author to whom correspondence should be addressed.
Received: 20 April 2012 / Revised: 17 May 2012 / Accepted: 1 June 2012 / Published: 14 June 2012
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Abstract

Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed. View Full-Text
Keywords: sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Teta, R.; Della Sala, G.; Renga, B.; Mangoni, A.; Fiorucci, S.; Costantino, V. Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator. Mar. Drugs 2012, 10, 1383-1390.

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