Mar. Drugs 2012, 10(3), 668-676; doi:10.3390/md10030668
Article

Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus

1,2,3email, 2email, 4email, 2email, 2email, 1email, 2email and 2,* email
Received: 14 February 2012; in revised form: 8 March 2012 / Accepted: 10 March 2012 / Published: 22 March 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two new antimycin A analogues, antimycin B1 and B2 (12), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
Keywords: marine-derived actinomycete; Streptomyces lusitanus; antibacterial; antimycin B
PDF Full-text Download PDF Full-Text [252 KB, uploaded 23 March 2012 08:38 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Han, Z.; Xu, Y.; McConnell, O.; Liu, L.; Li, Y.; Qi, S.; Huang, X.; Qian, P. Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus. Mar. Drugs 2012, 10, 668-676.

AMA Style

Han Z, Xu Y, McConnell O, Liu L, Li Y, Qi S, Huang X, Qian P. Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus. Marine Drugs. 2012; 10(3):668-676.

Chicago/Turabian Style

Han, Zhuang; Xu, Ying; McConnell, Oliver; Liu, Lingli; Li, Yongxin; Qi, Shuhua; Huang, Xiangzhong; Qian, Peiyuan. 2012. "Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus." Mar. Drugs 10, no. 3: 668-676.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert