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Mar. Drugs 2012, 10(3), 668-676; doi:10.3390/md10030668
Article

Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus

1,2,3
, 2
, 4
, 2
, 2
, 1
, 2
 and 2,*
1 Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China 2 Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China 3 Graduate School of the Chinese Academy of Sciences, Beijing 100049, China 4 John I. Haas, Inc., Yakima, WA 98902, USA
* Author to whom correspondence should be addressed.
Received: 14 February 2012 / Revised: 8 March 2012 / Accepted: 10 March 2012 / Published: 22 March 2012
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Abstract

Two new antimycin A analogues, antimycin B1 and B2 (12), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
Keywords: marine-derived actinomycete; Streptomyces lusitanus; antibacterial; antimycin B marine-derived actinomycete; Streptomyces lusitanus; antibacterial; antimycin B
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Han, Z.; Xu, Y.; McConnell, O.; Liu, L.; Li, Y.; Qi, S.; Huang, X.; Qian, P. Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus. Mar. Drugs 2012, 10, 668-676.

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