Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

doi:10.3390/md10020319

This article is

freely available
re-usable

Mar. Drugs 2012, 10(2), 319-328; doi:10.3390/md10020319

Article

Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Yongxin Li¹, Ying Xu¹, Lingli Liu¹, Zhuang Han¹, Pok Yui Lai¹, Xiangrong Guo², Xixiang Zhang², Wenhan Lin³ and Pei-Yuan Qian^1,*

¹ KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China ² Advanced Nano-fabrication, Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia ³ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China

* Author to whom correspondence should be addressed.

Received: 20 December 2011; in revised form: 29 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012

Download PDF Full-Text [263 KB, uploaded 3 February 2012 11:04 CET]

Abstract: Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

Keywords: antibacterial; cytotoxicity; lipoamicoumacin; Bacillus subtilis

Supplementary Files

Supplementary File 1:
PDF-Document (PDF, 8487 KB)

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Li, Y.; Xu, Y.; Liu, L.; Han, Z.; Lai, P.Y.; Guo, X.; Zhang, X.; Lin, W.; Qian, P.-Y. Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Mar. Drugs 2012, 10, 319-328.

AMA Style

Li Y, Xu Y, Liu L, Han Z, Lai PY, Guo X, Zhang X, Lin W, Qian P-Y. Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Marine Drugs. 2012; 10(2):319-328.

Chicago/Turabian Style

Li, Yongxin; Xu, Ying; Liu, Lingli; Han, Zhuang; Lai, Pok Yui; Guo, Xiangrong; Zhang, Xixiang; Lin, Wenhan; Qian, Pei-Yuan. 2012. "Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis." Mar. Drugs 10, no. 2: 319-328.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert