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Mar. Drugs 2012, 10(12), 2741-2748; doi:10.3390/md10122741
Article

Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.

1
, 1
, 2
, 3
 and 1,*
1 Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan 2 Biological Resources Section, Research Support Division, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan 3 Department of Bioresource Technology, Okinawa National College of Technology, Nago-shi, Okinawa 905-2192, Japan
* Author to whom correspondence should be addressed.
Received: 24 October 2012 / Revised: 23 November 2012 / Accepted: 26 November 2012 / Published: 30 November 2012
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Abstract

Five new diterpenoids 15 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC50 5.85 μM), while these new diterpenoids 15 were much less active (IC50 28.2–91.4 μM).
Keywords: Cespitularia; cytotoxicity; diterpenoid; HCT 116 cells; alcyonolide Cespitularia; cytotoxicity; diterpenoid; HCT 116 cells; alcyonolide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Roy, P.K.; Maarisit, W.; Roy, M.C.; Taira, J.; Ueda, K. Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.. Mar. Drugs 2012, 10, 2741-2748.

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