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Mar. Drugs 2012, 10(12), 2715-2728; doi:10.3390/md10122715
Article

Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin

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Received: 30 October 2012; in revised form: 13 November 2012 / Accepted: 22 November 2012 / Published: 30 November 2012
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Abstract: Deoxybostrycin (1) is an anthraquinone compound derived from the marine mangrove fungus Nigrospora sp. No. 1403 and has potential to be a lead for new drugs because of its various biological properties. A series of new derivatives (222) of deoxybostrycin were synthesized. The in vitro cytotoxicity of all the new compounds was tested against MDA-MB-435, HepG2 and HCT-116 cancer cell lines. Most of the compounds exhibit strong cytotoxicity with IC50 values ranging from 0.62 to 10 μM. Compounds 19, 21 display comparable cytotoxicity against MDA-MB-435 to epirubicin, the positive control. The primary screening results indicate that the deoxybostrycin derivatives might be a valuable source of new potent anticancer drug candidates.
Keywords: deoxybostrycin derivatives; antitumor activity; marine mangrove; anthraquinone deoxybostrycin derivatives; antitumor activity; marine mangrove; anthraquinone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, H.; Zhu, X.; Zhong, L.-L.; Yang, B.; Li, J.; Wu, J.-H.; Chen, S.-P.; Lin, Y.-C.; Long, Y.; She, Z.-G. Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin. Mar. Drugs 2012, 10, 2715-2728.

AMA Style

Chen H, Zhu X, Zhong L-L, Yang B, Li J, Wu J-H, Chen S-P, Lin Y-C, Long Y, She Z-G. Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin. Marine Drugs. 2012; 10(12):2715-2728.

Chicago/Turabian Style

Chen, Hong; Zhu, Xun; Zhong, Li-Li; Yang, Bing; Li, Jia; Wu, Jue-Heng; Chen, Sheng-Ping; Lin, Yong-Cheng; Long, Yuhua; She, Zhi-Gang. 2012. "Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin." Mar. Drugs 10, no. 12: 2715-2728.


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