Targeting TRPM2 in ROS-Coupled Diseases
AbstractUnder pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease. The second member of the transient receptor potential (TRP) melastatin subfamily, TRPM2, is a Ca2+-permeable non-selective cation channel, activated by ROS in an ADP-ribose mediated fashion. In other words, TRPM2 functions as a transducer that converts oxidative stress into Ca2+ signaling. There is good evidence that TRPM2 plays an important role in ROS-coupled diseases. For example, in monocytes the influx of Ca2+ through TRPM2 activated by ROS contributes to the aggravation of inflammation via chemokine production. In this review, the focus is on TRPM2 as a molecular linker between ROS and Ca2+ signaling in ROS-coupled diseases. View Full-Text
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Yamamoto, S.; Shimizu, S. Targeting TRPM2 in ROS-Coupled Diseases. Pharmaceuticals 2016, 9, 57.
Yamamoto S, Shimizu S. Targeting TRPM2 in ROS-Coupled Diseases. Pharmaceuticals. 2016; 9(3):57.Chicago/Turabian Style
Yamamoto, Shinichiro; Shimizu, Shunichi. 2016. "Targeting TRPM2 in ROS-Coupled Diseases." Pharmaceuticals 9, no. 3: 57.