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Pharmaceuticals 2016, 9(2), 26; doi:10.3390/ph9020026

How Efficient Is My (Medicinal) Chemistry?

Laboratory of Organic Chemistry, University of Mons-UMONS, Place du Parc 23, Mons B-7000, Belgium
Academic Editor: Derek J. McPhee
Received: 27 January 2016 / Revised: 3 May 2016 / Accepted: 10 May 2016 / Published: 16 May 2016
(This article belongs to the Collection Choices of the Journal)
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Abstract

“Greening” a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of paracetamol in order to understand their performance parameters and elucidate pathways for improvement. View Full-Text
Keywords: atom economy; ecoscale; E factor; green chemistry; life cycle analysis; paracetamol; reaction mass efficiency; stoichiometric factor; waste; yield atom economy; ecoscale; E factor; green chemistry; life cycle analysis; paracetamol; reaction mass efficiency; stoichiometric factor; waste; yield
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vanden Eynde, J.J. How Efficient Is My (Medicinal) Chemistry? Pharmaceuticals 2016, 9, 26.

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