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Pharmaceuticals 2014, 7(4), 392-418; doi:10.3390/ph7040392
Review

Radiolabeling of Nanoparticles and Polymers for PET Imaging

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Received: 23 December 2013; in revised form: 4 March 2014 / Accepted: 10 March 2014 / Published: 2 April 2014
(This article belongs to the Special Issue Radiopharmaceutical Chemistry between Imaging and Radioendotherapy)
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Abstract: Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screening/selection and monitoring. Hence, labeling methods for potential drug delivery systems are an indispensable need to provide the radiolabeled analog. In this review, we describe and discuss various approaches and methods for the labeling of potential drug delivery systems using positron emitters.
Keywords: positron emitter; radiolabeling; nanoparticles; polymers; drug delivery; PET; imaging; nanomedicine positron emitter; radiolabeling; nanoparticles; polymers; drug delivery; PET; imaging; nanomedicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Stockhofe, K.; Postema, J.M.; Schieferstein, H.; Ross, T.L. Radiolabeling of Nanoparticles and Polymers for PET Imaging. Pharmaceuticals 2014, 7, 392-418.

AMA Style

Stockhofe K, Postema JM, Schieferstein H, Ross TL. Radiolabeling of Nanoparticles and Polymers for PET Imaging. Pharmaceuticals. 2014; 7(4):392-418.

Chicago/Turabian Style

Stockhofe, Katharina; Postema, Johannes M.; Schieferstein, Hanno; Ross, Tobias L. 2014. "Radiolabeling of Nanoparticles and Polymers for PET Imaging." Pharmaceuticals 7, no. 4: 392-418.



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