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Pharmaceuticals 2012, 5(2), 209-235; doi:10.3390/ph5020209
Review

Structure Based Antibody-Like Peptidomimetics

1,2,*  and 2,*
Received: 16 December 2011; in revised form: 17 January 2012 / Accepted: 19 January 2012 / Published: 16 February 2012
(This article belongs to the Special Issue Peptidomimetics)
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Abstract: Biologics such as monoclonal antibodies (mAb) and soluble receptors represent new classes of therapeutic agents for treatment of several diseases. High affinity and high specificity biologics can be utilized for variety of clinical purposes. Monoclonal antibodies have been used as diagnostic agents when coupled with radionuclide, immune modulatory agents or in the treatment of cancers. Among other limitations of using large molecules for therapy the actual cost of biologics has become an issue. There is an effort among chemists and biologists to reduce the size of biologics which includes monoclonal antibodies and receptors without a reduction of biological efficacy. Single chain antibody, camel antibodies, Fv fragments are examples of this type of deconstructive process. Small high-affinity peptides have been identified using phage screening. Our laboratory used a structure-based approach to develop small-size peptidomimetics from the three-dimensional structure of proteins with immunoglobulin folds as exemplified by CD4 and antibodies. Peptides derived either from the receptor or their cognate ligand mimics the functions of the parental macromolecule. These constrained peptides not only provide a platform for developing small molecule drugs, but also provide insight into the atomic features of protein-protein interactions. A general overview of the reduction of monoclonal antibodies to small exocyclic peptide and its prospects as a useful diagnostic and as a drug in the treatment of cancer are discussed.
Keywords: antibody; CDR; peptidomimetics; Her2; Herceptin; drug-delivery; therapeutics; tumor imaging; AHNP; AERP antibody; CDR; peptidomimetics; Her2; Herceptin; drug-delivery; therapeutics; tumor imaging; AHNP; AERP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Murali, R.; Greene, M.I. Structure Based Antibody-Like Peptidomimetics. Pharmaceuticals 2012, 5, 209-235.

AMA Style

Murali R, Greene MI. Structure Based Antibody-Like Peptidomimetics. Pharmaceuticals. 2012; 5(2):209-235.

Chicago/Turabian Style

Murali, Ramachandran; Greene, Mark I. 2012. "Structure Based Antibody-Like Peptidomimetics." Pharmaceuticals 5, no. 2: 209-235.


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