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• Muneyyirci-Delale, O
• Chandrareddy, A
• Mankame, S
• Osei-Tutu, N
• Gizycki, H
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• Muneyyirci-Delale, O
• Chandrareddy, A
• Mankame, S
• Osei-Tutu, N
• Gizycki, H
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• Muneyyirci-Delale, O
• Chandrareddy, A
• Mankame, S
• Osei-Tutu, N
• Gizycki, H

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Pharmaceuticals 2012, 5(10), 1120-1127; doi:10.3390/ph5101120

Article

Norethindrone Acetate in the Medical Management of Adenomyosis

Ozgul Muneyyirci-Delale ^1,2,* , Ashadeep Chandrareddy ¹ , Siddhi Mankame ¹ , Nanna Osei-Tutu ¹  and Hans von Gizycki ³

¹ Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA ² Department of Obstetrics and Gynecology, Kings County Hospital Center, 451 Clarkson Avenue, Brooklyn, NY 11203, USA ³ Scientific Computing Center, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA

* Author to whom correspondence should be addressed.

Received: 8 July 2012; in revised form: 4 October 2012 / Accepted: 15 October 2012 / Published: 22 October 2012

(This article belongs to the Special Issue Hormone Therapy)

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Abstract: The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was significant improvement of both dysmenorrhea and bleeding after treatment. Age showed no correlation with dysmenorrhea or bleeding. Low dose NA could be considered an effective, well-tolerated and inexpensive medical alternative to surgery for treating symptomatic adenomyosis. Large multicentric studies may help validate our findings.

Keywords: norethindrone acetate; adenomyosis; dysmenorrhea

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