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Pharmaceuticals 2012, 5(10), 1120-1127; doi:10.3390/ph5101120
Article

Norethindrone Acetate in the Medical Management of Adenomyosis

1,2,* , 1, 1, 1 and 3
1 Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA 2 Department of Obstetrics and Gynecology, Kings County Hospital Center, 451 Clarkson Avenue, Brooklyn, NY 11203, USA 3 Scientific Computing Center, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
* Author to whom correspondence should be addressed.
Received: 8 July 2012 / Revised: 4 October 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Hormone Therapy)
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Abstract

The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was significant improvement of both dysmenorrhea and bleeding after treatment. Age showed no correlation with dysmenorrhea or bleeding. Low dose NA could be considered an effective, well-tolerated and inexpensive medical alternative to surgery for treating symptomatic adenomyosis. Large multicentric studies may help validate our findings.
Keywords: norethindrone acetate; adenomyosis; dysmenorrhea norethindrone acetate; adenomyosis; dysmenorrhea
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Muneyyirci-Delale, O.; Chandrareddy, A.; Mankame, S.; Osei-Tutu, N.; Gizycki, H. Norethindrone Acetate in the Medical Management of Adenomyosis. Pharmaceuticals 2012, 5, 1120-1127.

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