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Pharmaceuticals 2012, 5(10), 1120-1127; doi:10.3390/ph5101120
Article

Norethindrone Acetate in the Medical Management of Adenomyosis

1,2,* , 1, 1, 1 and 3
Received: 8 July 2012; in revised form: 4 October 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Hormone Therapy)
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Abstract: The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was significant improvement of both dysmenorrhea and bleeding after treatment. Age showed no correlation with dysmenorrhea or bleeding. Low dose NA could be considered an effective, well-tolerated and inexpensive medical alternative to surgery for treating symptomatic adenomyosis. Large multicentric studies may help validate our findings.
Keywords: norethindrone acetate; adenomyosis; dysmenorrhea norethindrone acetate; adenomyosis; dysmenorrhea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Muneyyirci-Delale, O.; Chandrareddy, A.; Mankame, S.; Osei-Tutu, N.; Gizycki, H. Norethindrone Acetate in the Medical Management of Adenomyosis. Pharmaceuticals 2012, 5, 1120-1127.

AMA Style

Muneyyirci-Delale O, Chandrareddy A, Mankame S, Osei-Tutu N, Gizycki H. Norethindrone Acetate in the Medical Management of Adenomyosis. Pharmaceuticals. 2012; 5(10):1120-1127.

Chicago/Turabian Style

Muneyyirci-Delale, Ozgul; Chandrareddy, Ashadeep; Mankame, Siddhi; Osei-Tutu, Nanna; Gizycki, Hans von. 2012. "Norethindrone Acetate in the Medical Management of Adenomyosis." Pharmaceuticals 5, no. 10: 1120-1127.



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