Next Article in Journal / Special Issue
Opioid Antagonists May Reverse Endogenous Opiate “Dependence” in the Treatment of Self-Injurious Behavior
Previous Article in Journal
Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs)
Previous Article in Special Issue
Pharmacological Evaluation of 3-Carbomethoxy Fentanyl in Mice
Pharmaceuticals 2011, 4(2), 343-365; doi:10.3390/ph4020343
Review

Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and Anesthesia

* ,
 and
Department of Physiology, Saga Medical School,5-1-1 Nabeshima, Saga 849-8501, Japan
* Author to whom correspondence should be addressed.
Received: 14 December 2010 / Revised: 17 January 2011 / Accepted: 25 January 2011 / Published: 28 January 2011
(This article belongs to the Special Issue Opioids)
View Full-Text   |   Download PDF [573 KB, uploaded 28 January 2011]   |   Browse Figures
SciFeed

Abstract

Opioids inhibit glutamatergic excitatory transmission from the periphery by activating G-protein coupled opioid receptors in the central terminals of primary-afferent neurons in the spinal substantia gelatinosa, resulting in antinociception. Opioid receptor activation in the peripheral terminals of primary-afferent neurons inhibits the production of action potentials in response to nociceptive stimuli given to the periphery, leading to antinociception. Opioids also exhibit a local anesthetic effect without opioid receptor activation in peripheral nerve fibers. This review article will focus on analgesia and anesthesia produced by the actions of opioids on primary-afferent fibers.
Keywords: opioids; spinal dorsal horn; excitatory synaptic transmission; primary-afferent fiber; action potential conduction opioids; spinal dorsal horn; excitatory synaptic transmission; primary-afferent fiber; action potential conduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Kumamoto, E.; Mizuta, K.; Fujita, T. Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and Anesthesia. Pharmaceuticals 2011, 4, 343-365.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert