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Pharmaceuticals 2010, 3(8), 2674-2688; doi:10.3390/ph3082674

Overview of Histone Deacetylase Inhibitors in Haematological Malignancies

1
Cancer Immunology Research, Peter MacCallum Cancer Centre, Melbourne, Australia
2
Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Australia
3
University of Melbourne, Parkville, Melbourne, Australia
*
Author to whom correspondence should be addressed.
Received: 23 July 2010 / Revised: 12 August 2010 / Accepted: 13 August 2010 / Published: 17 August 2010
(This article belongs to the Special Issue HDAC Inhibitors)
View Full-Text   |   Download PDF [163 KB, uploaded 17 August 2010]

Abstract

Histone deacetylase inhibitors (HDACi) can induce hyperacetylation of both histone and non-histone target resulting in epigenetic reprogramming and altered activity, stability and localisation of non-histone proteins to ultimately mediate diverse biological effects on cancer cells and their microenvironment. Clinical trials have demonstrated single agent HDACi to have activity in hematological malignancies, in particular T-cell lymphoma and Hodgkin lymphoma. Combination strategies with standard therapies based on pre-clinical data are being employed with significant success due to their excellent side effect profile. Correlative studies will provide valuable information on the sub-groups of patients more likely to respond or be resistant to HDACi therapy, while long-term monitoring for toxicities is also needed.
Keywords: Histone deacetylase inhibitors; Clinical studies; Haematology Histone deacetylase inhibitors; Clinical studies; Haematology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bishton, M.J.; Johnstone, R.W.; Dickinson, M.; Harrison, S.; Prince, H.M. Overview of Histone Deacetylase Inhibitors in Haematological Malignancies. Pharmaceuticals 2010, 3, 2674-2688.

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