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EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment
Oncopharmacology Unit, Centre Antoine Lacassagne, 33 Ave Valombrose, 06100 Nice, France
Department of Gerontology, Centre Hospitalier et Universitaire de Nice, Hôpital de Cimiez, 4 Ave Reine Victoria, 06000 Nice, France
University of Nice Sophia-Antipolis, Nice, France
* Author to whom correspondence should be addressed.
Received: 25 May 2010; in revised form: 6 July 2010 / Accepted: 14 July 2010 / Published: 19 July 2010
Abstract: The incidence of prostate cancer increases with age and because of its high prevalence this disease has become a major public health concern. Despite advances in our understanding of the biological mechanisms responsible for the development of this cancer, the transition to the hormone refractory stage (HRPC) and metastatic progression pose real problems of clinical management. Currently, docetaxel chemotherapy has been shown to have a slight but significant impact on survival, though the gain in median survival is still less than three months. Research is therefore continuing to improve treatment outcomes. The progression of prostate cancer is accompanied by the overexpression of EGFR (epidermal growth factor receptor) in a very large majority of cases, suggesting that this may play a mechanistic role. Unfortunately, although preclinical findings seem to be promising for therapies targeting the EGFR in HRPC, current clinical results are disappointing. These results should however encourage us to look for different ways of using anti-EGFR agents or combining them with other targeted therapies.
Keywords: chemotherapy; targeted therapy; EGFR; kinase inhibitors; prostate cancer; hormone-resistant prostate cancer; geriatric oncology
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Guérin, O.; Fischel, J.L.; Ferrero, J.-M.; Bozec, A.; Milano, G. EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment. Pharmaceuticals 2010, 3, 2238-2247.
Guérin O, Fischel JL, Ferrero J-M, Bozec A, Milano G. EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment. Pharmaceuticals. 2010; 3(7):2238-2247.
Guérin, Olivier; Fischel, Jean Louis; Ferrero, Jean-Marc; Bozec, Alexandre; Milano, Gerard. 2010. "EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment." Pharmaceuticals 3, no. 7: 2238-2247.