Pharmaceuticals 2010, 3(7), 2238-2247; doi:10.3390/ph3072238
Review

EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment

1,2,3,* email, 1, 1,3, 1 and 1
Received: 25 May 2010; in revised form: 6 July 2010 / Accepted: 14 July 2010 / Published: 19 July 2010
(This article belongs to the Special Issue Targeted Therapy)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The incidence of prostate cancer increases with age and because of its high prevalence this disease has become a major public health concern. Despite advances in our understanding of the biological mechanisms responsible for the development of this cancer, the transition to the hormone refractory stage (HRPC) and metastatic progression pose real problems of clinical management. Currently, docetaxel chemotherapy has been shown to have a slight but significant impact on survival, though the gain in median survival is still less than three months. Research is therefore continuing to improve treatment outcomes. The progression of prostate cancer is accompanied by the overexpression of EGFR (epidermal growth factor receptor) in a very large majority of cases, suggesting that this may play a mechanistic role. Unfortunately, although preclinical findings seem to be promising for therapies targeting the EGFR in HRPC, current clinical results are disappointing. These results should however encourage us to look for different ways of using anti-EGFR agents or combining them with other targeted therapies.
Keywords: chemotherapy; targeted therapy; EGFR; kinase inhibitors; prostate cancer; hormone-resistant prostate cancer; geriatric oncology
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MDPI and ACS Style

Guérin, O.; Fischel, J.L.; Ferrero, J.-M.; Bozec, A.; Milano, G. EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment. Pharmaceuticals 2010, 3, 2238-2247.

AMA Style

Guérin O, Fischel JL, Ferrero J-M, Bozec A, Milano G. EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment. Pharmaceuticals. 2010; 3(7):2238-2247.

Chicago/Turabian Style

Guérin, Olivier; Fischel, Jean Louis; Ferrero, Jean-Marc; Bozec, Alexandre; Milano, Gerard. 2010. "EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment." Pharmaceuticals 3, no. 7: 2238-2247.

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